Achyranthes Aspera Linn., known as Chirchira (Hindi), Agadha (Marathi) is an indigenous herb found in India. Agadha is the basic composition of many traditional remedies. It is commonly used for the treatment of fever, dysentery, asthma, hypertension, diabetes, cough, bronchitis and rheumatism. Present study was designed to evaluate the analgesic (antinociceptive) activity of an ethanol extract of Achyranthes Aspera (Agadha). Findings of this study may help researchers to set their minds for studying the utility, efficacy and potency of herb as an analgesic.The ethanol extract of A. Aspera was examined for its central analgesic activity by using hot plate, tail flick method in albino mice. The doses administered were 200 mg/kg and 400 mg/kg p.o. (orally). The Pentazocine10mg/kg i.p. (intraperitoneal) was taken as standard drug.Data analyzed by ANOVA test followed by Dunnett’s test. All the results were expressed as Mean (±SEM). P <0.05 was considered significant. The animal that administered a dose of 400mg/kg leaf extract has shown the maximum analgesic activity comparable to Pentazocine (p<0.001). The analgesic activity was observed after 60min of drug administration and showed wearing off after 120mins. An ethanol extract of A. Aspera has central analgesic activity involving spinal as well as supraspinal mechanisms. This activity may be due to saponins found in the extract. Extrapolation of findings in clinical situation however needed to develop it as novel analgesic.
Loading....